LCAOS - LCAOS newsletter

LCaos Newsletter - Issue no.4

Silvia Birsan — Wed, 23 Oct 2013 06:34:39 +0000

Welcome!

Dear Readers,

You are welcome to our new issue of the LCaos Newsletter. As you know, the purpose of this newsletter is to bring you the latest news coming from our FP7 LCaos consortium activities and achievements.

The opening section, Former Events, describes activities or actions organized or related to the LCaos project. The following section, LCaos Activities & Achievements, refers to the General Assembly Meeting that took place on 13 June 2013 in Saarbrücken/Wallerfangen, Germany. The LCaos Technical Developments section contains information about the technical developments and current work status, as well as some major outcomes and plans for the future. The next section, LCaos Events, Publications and Awards advertises relevant workshops and conferences, and a list of publications and awards resulting from the project’s activities. Finally, the LCaos Exchanges and Position Openings section is dedicated to exchange opportunities and position openings. This is the place for each partner to advertise any M.Sc, Ph.D or post-doctoral open position, or any opportunities and exchanges for visiting researchers.

We really hope you will enjoy reading this newsletter! In the same time, we highly encourage all our readers to send us feedbacks and comments. We would also be pleased to receive more pictures and contributions from all our project partners!

Wishing you success in your research and lectures!

Prof. Hossam Haick and Dr. Silvia Birsan
LCaos Newsletter

LCaos Former Events

The first LCaos workshop and the ISOCS training sessions – one big success for LCaos Consortium!

The first Workshop on Lung Cancer Artificial Olfactory System (LCaos( was organized on June 13, 2013, in Saarbrücken/Wallerfangen, Germany.
The LCaos workshop was jointly organized by the LCaos Consortium, the Breath Analysis Summit 2013 (June 9-12, 2013) and the ISOCS Short Course on Chemical Sensors for Breath Analysis (June 14, 2013). All events took place in the same location. The LCaos workshop aimed to bring the latest updates on volatile markers for early diagnosis and classification of lung cancer. Additionally, the workshop aimed to pass to the audience the latest updates on chemical sensors and nanoarrays for the diagnosis of lung cancer via volatile markers. The LCaos workshop brought together scientists, clinicians, industry executives, and entrepreneurs who discussed key trends, future directions, and technologies available for chemical sensors and nanoarrays for lung cancer diagnosis via volatile markers.

ISOCS Short Course was organized on June 14, 2013 in the same place: Wallerfangen, Germany and most of the LCaos Consortium partners joined it as organizers or/and lectures.
The Short Course explored chemical sensors in breath analysis, provided knowledge on chemical sensors, covered the field of data analysis and breath analysis for lung cancer detection, and established medical practices for lung cancer detection. The main objective was to give an overview on the available technologies and current research, with a focus on practical applicability and real life problems. The short course was intended for medical scientists, clinicians and industrialists who want to get a head start on chemical sensors in breath analysis, as well as for researchers and engineers who want to use their technology in lung cancer breath analysis.

LCaos Activities and Achievements

4th General Assembly Meeting

On 13 June 2013 the 4th General Assembly Meeting of LCaos project took place in Wallerfangen, Germany – an event organized by our project partner JLM Innovation together with the Technion. The Public Session welcomed the LCaos members as well as other invited participants. Each WP leader presented the evolution of the project from the scientific and technical points of view, as well as the progress and results achieved during the last six-month period until June 2013. During the Internal Session, there were consultations on future project plans, on dissemination and administrative issues, and on the reporting process. All the participants valued the meeting that gave a comprehensive vision on the progress we made and on our future plans.

LCaos Technical Developments

The Max Planck Institute for the Science of Light has fabricated silicon nanowires (Si NWs) by bottom-up (growth) and top-down (etching) methods. The different processes are fully understood and can be used to form SiNWs of different aspect ratios, doping and structural / chemical surface properties and Si NW arrays of different geometries. Si NWs were grown by the vapor liquid solid (VLS) method with an average diameter of 50-100 nm, average lengths of 1-20 µm and different doping levels. The array geometries can be tuned by controlled deposition of the VLS catalysts by lithographic techniques. Further SiNWs were produced by reactive ion etching (RIE) in combination with polystyrene nanosphere (PS) lithography. Here average diameters of 0.5-1µm and average lengths of 1-6µm could be achieved. The chemical / physical properties of SiNW surfaces were modified, in order to optimize junctions / interfaces in SiNW based device applications. The surface roughness as well as the passivation of dangling bonds could be modified by various wet chemical approaches. Further, the SiNW doping and the work function could be tuned by controlled oxidation of the SiNW surfaces. Si NWs were characterized by advanced imaging techniques, such as scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The surface properties of the Si NW were analyzed by X-ray photoelectron spectroscopy (XPS) whereas electronic properties could be monitored by contacting single NW device structures and performing photo- and cathodoluminescence (PL, CL) studies.


                                    SEM micrograph of the Si NW fabricated by: (a) RIE (top down) and (b) CVD.

The Technion has developed selective detection of lung cancer biomarkers in the gas. The Technion team have shown that an ensemble of independent device parameters extracted from single Si Nanowire Field Effect Transistor (SiNW FET) in combination with artficial intelligence could provide high selectivity towards specific VOCs. The effect of the backbone and functional (head) groups of the recognition layer attached to the Si NW surface on the obtained sensing results is presented and discussed. We show additionally that this approach can’t only detect specific VOCs, but, also, can predict their concentrations in the gas phase. The selectivity of the examined devices towards a single VOC that is found in a mixture of VOCs has been achieved.

Following the fabrication of the exposure cells in the first year of the project, Micronit Partner has developed a holder that forms the fluidic and electrical interface between the exposure cells and external equipment. The holder accommodates two exposure cells equipped with 8 sensor chips each which can be run in parallel analyzing the sample from one source or two sources simultaneously. The exposure cells can be exchanged in a matter of seconds for example to switch to an alternate set of sensor chips with different response characteristics for the samples that are being analyzed. A picture of the holder is shown below:



The Liverpool University and Technion partners have completed a series of experiments on in-vitro headspace VOC analysis for cell-lines that represent normal airway epithelial cells and the earliest precursors of lung cancer with defined genetic alterations. The has been extended to include discriminant factor analysis with NaNose sensor arrays, with between 1 and 3 sensor features being demonstrated to accurately identify each of 4 cell-lines with single mutation differences. This work will be presented at the LCAOS workshop in June.

In support of both the in vitro cancer cell-line analysis of the Tel-Aviv University partner and the identification of cancer risk biomarkers by the Liverpool University partner, next-generation genomic DNA sequencing is being carried out. The risk biomarker work includes on-going bioinformatic analysis of microRNA and DNA methylation data. Epidemiology-based lung cancer risk scores including the Liverpool Lung Project (LLP) model are also being integrated into VOC analysis of breath samples in collaboration between Liverpool University, Tel-Aviv University and Technion partners. In Liverpool, these samples are now being collected within LLP clinics, hospital and community medicine settings.



The Tel-Aviv University has achieved important milestones in the early detection of lung cancer by the sensors array developed in the LCaos project. The Tel-Aviv University team has achieved high accuracy in discriminating malignant nodules vs. non-malignant pulmonary nodules. Moreover, this team could discriminate between subtypes of lung cancer, NSCLC vs. SCLC, as describes in the following figure:



Up to date, the Tel-Aviv University collected exhaled breath samples from 112 participating: 80 are lung cancer patients, 22 individuals with nodules for follow-up, 4 participants are COPD patients or heavy smokers and 6 participants are healthy controls. The exhaled breath samples were delivered to the Technion for sensors array and GC-MS analyses. The Tel-Aviv University team constructed a clinical database gathering clinical and epidemiological information from each patient including health status, pathological classification, scan results (CT, PET-CT and SUV avidity), size and tumor location, disease status and epidemiological data (age, gender, smoking history, respiratory diseases, pollutant exposure etc.). The team has also monitored patients who are under systemic therapy for lung cancer, aiming to allocate the specific VOCs that might have association with response (or progression). So far, the team enrolled 27 patients; 24 patients have NSCLC and 3 patients have SCLC. The subsets have been determined as follows: (a) conventional chemotherapy regimen; (b) targeted therapy (e.g. EGFR, TKI, erlotinib); Breath samples are collected and the signatures are crossed-matched with tumor response, which is assessed by routine CT scan imaging, and be measured by the RECIST criteria. This follow up is still on-going.

In parallel to the breath analysis of lung cancer, the Tel-Aviv University team has reported that nanomaterial-based sensors array can discriminate between lung cancer subtypes, i.e. adenocarcinomas and squamous cell carcinoma. Moreover, the team has shown that the sensors array is also sensitive to genes abnormality, i.e. discriminating between EGFR, KRAS and ALK-EML4 mutants, as describes hereafter:



Last 7 June 2013 the 1st Multidisciplinary Conference of Cancer took place at the Complutense University in Madrid (Spain). The reached objective of this event, which was run by Dr. José S. Torrecilla, Professor of the Chemical Engineering Department of the same university, was to help understand the multiple fields that are involved and necessary for cancer research. The close and dynamic attitude of the presentations favored the participation of the audience, which led to an active debate and interesting Q&A after every speech. All of the invited speakers, which were professors and researchers, highlighted that numerous disciplines must find the way to cooperate in order to attain one clear goal: win the fight against cancer by achieving its early diagnosis. Because of this, and after the success of this 1st Multidisciplinary Conference of Cancer, the organization will encourage the creation of future events meant for anyone interested in this matter.



In the current project period our project partner Ionimed has further tested the developed Liquid Calibration Unit (LCU) for simulation of artificial breath. The product itself and scientific posters have been presented at the PITTCON Conference & Expo 2013 (Philadelphia, USA), at spring meeting of the American Chemical Society (New Orleans, USA) and at the PTR-MS Conference (Obergurgl, Austria). In order to extend the range of usable solvents to others than water, a suitable micro-pump has been selected, with a better range of resistivity. To re-calibrate the flow-meters to other solvents a volumetric calibration procedure has been defined and tested. This allows also to use pure compounds to a large extend. The measurement of clinical breath samples with PTR-MS in Israel is currently ongoing. For the real-time analysis of breath samples from patients, Ionimed has developed a Buffered-End-Tidal breath sampler, which has recently passed the certification for clinical use. This breath sampling interface, development outside the LCAOS project, allows employing analyzer which do not comply with regulatory requirements to be used for clinical breath analysis. This would allow to rapidly bring a prototype of a sensor-based analyzers to a clinical level. The potential integration has been discussed with other work packages concerned with development of the NA-NOSE sampling setup. Furthermore, Ionimed has recently been merged with its parent company Ionicon Analytik. The necessary administrative procedures affecting Ionimed’s part in the LCAOS project have been investigated and are currently executed.

LCaos Events, Publications and Awards

Here is a selection of some relevant workshops and conferences attended by various LCaos teams during the last period:

E-MRS Spring Meeting, Strassbourg, France, 27-31 May 2013: Semiconductor nanowires in energy research
PVCT 2013, Aix-en-Provence, France, 22-24 May 2013: Semiconductor nanowires in energy research
GDR Nanofils Semiconducteurs, Montpellier, France, 02-05 April 2013: Semiconductor nanowires in energy research
MRS Spring Meeting, San Francisco, USA, 01-05 April 2013: Semiconductor nanowires in energy research
DPG 13, Regensburg, Germany, 10-15 March 2013: Semiconductor Nanowires in Energy Research
Annual meeting Photonic Devices - ZIB, Berlin, Germany, 21-22 February 2013: Semiconductor nanowires in energy research
OSA International Congress on Renewable Energy and the Environment, Eindhoven, Netherlands, 11-15 November 2012: Semiconductor Nanowires in Energy Research
Asia Communication & Photonics Conference- ACP2012, Guangzhou, China, 07-10 November 2012: Semiconductor Nanowires in Photovoltaic and Sensing Applications
SPIE Optics & Photonics: Conference 8471: Next Generation (Nano) Photonic & Cell Technologies for Solar Energy Conversion, San Diego, USA, 14-17 September 2012: Semiconductor Nanowires for Photovoltaic Applications

Relevant publications issued by LCaos teams:

Bashouti, Y. M.; Pietsch, M.; Brönstrup, G.; Sivakov, V.; Ristein, J.; Christiansen, S. Hybrid polymer/silicon nanowire solar cell with high efficiency through covalent Si-C terminated surface passivation, Prog. Photovolt: Res. Appl. (accepted) (2013).
Bashouti, M. Y.; Sardashti, K.; Ristein, J.; Christiansen, S. Kinetic study of H-terminated silicon nanowires oxidation in very first stages, Nanoscale Res. Lett. 8, 41 (2013).
Bashouti, M. Y.; Pietsch, M.; Brönstrup, G.; Sivakov, V.; Ristein, J.; Christiansen, S. Hybrid polymer / silicon nanowire solar cell with high efficiency through covalent Si-C terminated surface passivation. Prog. Photovolt: Res. Appl. (ASAP) (2013).
Schmitt, W. S.; Schechtel, F.; Amkreutz, D.; Bashouti, M., Srivastava, S. K.; Hoffmann, B.; Dieker, C.; Spiecker, E.; Rech, B.; Christiansen, H. S. Nanowire Arrays in Multicrystalline Silicon Thin Films on Glass: A Promising Material for Research and Applications in Nanotechnology, Nano Lett. 12, 4050–4054 (2013).
Pietsch, M.; Bashouti, M. Y.; Christiansen, S. The Role of Hole Transport in Hybrid Inorganic/Organic Silicon/Poly(3,4-ethylenedioxy-thiophene):Poly(styrenesulfonate) Heterojunction Solar Cells, J. Phys. Chem. C 117, 9049–9055 (2013).
Konvalina, G; Haick, H.^* Sensors for Breath Testing: From Nanomaterials to Comprehensive Disease Detection. Acc. Chem. Res. (2013) (DOI: 10.1021/ar400070m)
Broza, Y.; Haick, H.^* Nanomaterial-based Sensors for Detection of Disease by Volatile Organic Compounds. Nanomedicine (London, UK) 8, 785-806 (2013)
Broza, Y.; Kremer, R.; Tisch, U.; Gevorkyan, A.; Abdah-Bortnyak, R.; Shiban, A.; Best, L. A.; Haick, H.^* A Nanomaterial-Based Breath Test for Short-Term Follow-Up after Lung Tumor Resection. Nanomedicine (New York, NY, US) 9(1), 15-21 (2013).
Peled, N.; Barash, O.; Tisch, U.; Ionescu, R.; Ilouze, M.; Mattei, M.; Bunn, P. A. Jr R., Hirsch, F. R.; Haick, H.^* Volatile Fingerprints of Cancer Specific Genetic Mutations. Nanomedicine (New York, NY, US) 9(6), 758-766 (2013).
Hakim, M.; Broza, Y. Y.; Barash, O.; Peled, N.; Phillips, M.; Amann, A.; Haick, H.^*Volatile Organic Compounds of Lung Cancer and Possible Biochemical Pathways. Chem. Rev. 112 (11), 5949–5966 (2012) – An Invited Review.
Peled, N.; Hakim, M.; Tisch, U.; Bunn, P. A. Jr. R.; Miller, Y. E.; Kennedy, T. C.; Mattei, J.; Mitchell, J. D.; Weyant, M. J.; Hirsch, F. R.; Haick, H.^* Non-invasive Breath Analysis of Pulmonary Nodules. J. Thorac. Oncol. 7(10), 1528-1533 (2012).
Tisch, U.; Billan, S.; Ilouze, M.; Phillips, M.; Peled, N.; Haick, H. Volatile Organic Compounds in the Exhaled Breath as Biomarkers for the Early Detection and Screening of Lung Cancer. CML – Lung Cancer 5(4), 107-117 (2012)

LCaos Exchanges and Position Openings

We are pleased to announce an open position on the team of Dr. Nir Peled (Tel Aviv University):
Position: M. Sc. student.
Responsibilities: Analyzing the PTR-MS results, comparing to molecules libraries, and identification of the metabolic pathways that the VOCs have originated from.
Education: M.Sc. student in Organic chemistry field.

LCaos Newsletter - Issues no . 2 & 3

Silvia Birsan — Wed, 23 Jan 2013 09:42:20 +0000

LCAOS newsletter

Welcome!

Dear Readers,

Welcome to the second & third issues of the LCaos Newsletter. This newsletter is intended to bring to you the latest news coming from our FP7 LCaos consortium activities and achievements.

The opening section is a new-added section, Upcoming Events, which announces happenings, activities or actions organized or related to the LCaos project. The following section, LCaos Activities & Achievements, describes the Board Meeting that took place on May 25, 2012 in Nuremberg, Germany and the General Assembly Meeting that took place on September 5-6, 2012 in Innsbruck, Austria. The LCaos Technical Developments section contains information about the technical developments and current work status, as well as some major outcomes and plans for the future. The next section, LCaos Events, Publications and Awards advertises relevant workshops and conferences, and a list of publications and awards resulting from the project’s activities. Finally, the LCaos Exchanges and Position Openings section is dedicated to exchange opportunities and position openings. This is the place for each partner to advertise any M.Sc, Ph.D or post-doctoral open position, or any opportunities and exchanges for visiting researchers.

We really hope you will enjoy reading this newsletter! In the same time, we highly encourage all our readers to send us feedback and comments. We would also be pleased to receive more pictures and contributions from all our project partners!

Wishing you success in your research and lectures!

Prof. Hossam Haick and Dr. Silvia Birsan
LCaos Newsletter

LCaos Upcoming Events

The first LCaos workshop and the ISOCS training sessions are approaching: June 2013!

The first Workshop on Lung Cancer Artificial Olfactory System - LCaos - will be organized on June 13-14, 2013, in Saarbrücken/Wallerfangen, Germany.

The LCaos workshop is jointly organized with the Breath Analysis Summit 2013 (June 9-12, 2013) and the ISOCS Short Course on Chemical Sensors for Breath Analysis (June 14, 2013). All events will take place at the same location. The LCaos workshop aims to bring the latest updates on volatile markers for early diagnosis and classification of lung cancer. Additionally, the workshop aims to being the latest updates on chemical sensors and nanoarrays for the diagnosis of lung cancer via volatile markers. The LCaos workshop will bring together scientists, engineers, clinicians, industry executives, and entrepreneurs to discuss key trends, future directions, and technologies available for chemical sensors and nanoarrays for lung cancer diagnosis via volatile markers.

Structure:
Oral and poster contributions are welcome. Abstracts have to be composed following the provided template. Abstracts have to be sent in via the LCaos website at www.lcaos.eu/workshop2013/ . Once your abstract is accepted, you will need to either prepare an oral presentation or to develop a poster. Instructions will follow along with acceptance.

Location:
The LCAOS Workshop will be held in Hotel Scheidberg, St. Vallier Straße 1, 66798 Wallerfangen/Kerlingen, Germany.

Major Deadlines:
Abstract submission:            February 15, 2013
Letter of acceptance:            February 25 2012
Registration of lecturers:     March 15, 2013
Early registration:                 March 31, 2013
Standard registration:          May 15, 2013
Late poster registration will be possible until May 15, 2013 in case space is available.

ISOCS Short Course will be organized on June 14, 2013 also in Hotel Scheidberg, Wallerfangen, Germany.

The Short Course explores chemical sensors in breath analysis provides and covers knowledge on chemical sensors, data analysis and breath analysis for lung cancer detection as well as established medical practices for lung cancer detection.
The main objective is to give an overview of the available technologies and current research with a focus on practical applicability and real life problems.
The short course is ideal for medical scientists, clinicians and industrialists who want to get a head start on chemical sensors in breath analysis, and for researchers and engineers who want to use their technology in lung cancer breath analysis.

Organizers and lecturers are Prof. Santiago Marco from the University of Barcelona, Spain and Dr. Jan Mitrovics from JLM Innovation GmbH, Germany. Additional invited lecturers are Prof Hossam Haick from the Technion Institute of Technology, Israel and Dr. Nir Peled from the Sheba Medical Center, Israel.

Further information you can get by visiting: www.olfactionsociety.org/course/breath201 or by contacting Dr. Jan Mitrovics (jan.mitrovics@jlm-innovation.de ) .

LCaos Activities and Achievements

Two fruitful meetings and one successful project!

The board (technical) meeting of LCaos project that took place on the 25^th of May 2012 in Nuremberg, Germany had a lot of similarities with the brainstorming meetings known from the high-tech world. The "technological-related" LCaos partners have met together for pushing forward the technological issues related to the development of the easy-to-use and easy-to-handle NA-NOSE device for instant diagnosis of the lung cancer.

The MPL group has reported on the synthesis and production of stand-alone silicon nanowires (Si NWs) by means of wet etching. Additionally, they reported on their studies to determine the kinetics and activation energy of the first stages of SiO2 growth in these Si NWs – an important observation that is needed for the functionalization of the Si NWs by the Technion team.

The Technion team has utilized the Si NWs produced by the MPL to fabricate molecule-terminated Si NW field effect transistors (Si NW FETs). In addition to these advances, the Technion team has reported on a new cost-effective (spray coating) method for the arrangement of Si NWs as an array of solid and flexible substrates. The method was patented and a publication describing the new technique was published in the prestigious ACS NANO journal.

Micronit has presented a preliminary prototype of the microfluidic system that host Si NW FETs produced by the Technion team, which, in turn, are based on the Si NWs produced in WP1. The devices were characterized electrically while being integrated in the microfluidic system. Some of the analysis was successful and the other ones showed a damage of the devices (most probably, during the shipment from Israel to the Netherlands). In addition, the team has presented a holder for the microfluidic system that enables integration with the electronic circuits developed by JLM.

JLM has presented a lab prototype consisting of several circuit board circuits that constitute a high resolution measurement system for SiNW FET sensors with large gate voltage range. The system is connected via USB to a PC and provides means to control the sampling valves and measure complete I/V curves for the SiNW sensors in a fraction of the time needed with before.No external device analyzers are needed any longer- huge saving of costs at improved measurement capabilities and very good step toward miniaturizing the designated NA-NOSE. At the time of the meeting, the system was ready but still required more electrical examinations by the JLM team.

The UCM team has reported on an advance on the pattern recognition methods they develop for the purpose of analyzing the sensing signals produced by the NA-NOSE. The team has presented an adapted version of the Neural Network analysis that is suited for analyzing the Si NW FET data, both as a spectrum and as matric of physical parameters (e.g., voltage threshold, on-current, off-current, hole mobility, sub-threshold voltage, etc.). An initial Matlab software that analyze the Si NW FET parameters as a function of time was presented and discussed.

IONIMED has presented a new prototype of gas generator system. This gas generator is based on nebulizing an aqueous calibration solution through a nozzle into a heated environment. The parameters affecting the achieved analyte’s concentrations were presented and discussed. Initial tests have shown that the developed gas generator is able to produce analytes at concentration levels that range between a few ppb to a few hundreds of ppm. IONIMED has reported also on her interaction with the TAU team and the Technion team providing them with the PTR-MS and the breath sampling device needed for clinical tests of breath samples from patients with lung cancer and healthy people.

LCaos project philosophy

On September 5-6, 2012, the 3rd General Assembly Meeting of LCaos project took place in Innsbruck, Austria – an event that was organized by our project partner IONIMED. The Opening Session welcomed the LCaos members as well as Prof. Anton Amann from Innsbruck Medical University – head of the Breath Research Institute of the Austrian Academy of Science. Following the welcome session, each WP leader presented the evolution of the project from the technical and scientific points of view, as well as the progress and results achieved from the beginning of the project April 2011 until September 2012. During the Closing Session, there were consultations on future project plans, on dissemination and administrative issues, on reporting and auditing processes, and on the preparation of the 1^st EC Periodic Report. The meeting also included a tour of the IONIMED laboratories, led by Dr. Jens Herbig, and to the volatile biomarkers laboratories, led by Prof. Anton Amann. All the participants appreciated the meeting for the opportunity of a global view on the current progress and on our future plans.

LCaos Technical Developments

The Max-Planck Institute partner has produced, by bottom-up and top-down approaches, silicon nanowires (Si NWs) with an average diameter of 50-100 nm and different doping levels. All Si NWs were characterized by advanced imaging techniques, such as scanning electron microscopy (SEM) and transmission electron microscopy (TEM).

The Technion partner has developed a spray-coating approach to allow aligned deposition of the Si NWs on a wide variety of solid and flexible devices. Additionally, the Technion partner has integrated both individual and Si NWs array with platforms of field effect transistors (FETs) and investigated cost-effective ways to use the resulting devices as sensors under real-world conditions. In this endeavor, the Technion team made a marked advance when they developed a molecularly-modified Si NW FET-based approach to detect polar and nonpolar gas analytes that are found in highly humidified samples.

In Liverpool University partners reported on a progress on several fronts. Using sampling techniques developed by the Tel-Aviv University partner and with analysis of Technion partner, they have embarked on in-vitro headspace VOC analysis for cell-lines that represent normal airway epithelial cells and the earliest precursors of lung cancer with defined genetic alterations. It has proved possible both to detect significant differences in the levels of defined VOCs by GC-MS and to discriminate between two closely related cell-lines with a single mutation. In order to understand the genetic basis of VOC discrimination of cancer subtypes, bioinformatics analysis is now tackling large datasets of genetic, expression and methylation data. These will be used to map tumour samples onto the molecular genealogy of lung cancer determined from these far larger datasets and to forecast the wider distribution of the VOC signatures measured in our own sample sets. In support of this, Liverpool University partner are also producing their own genetic datasets of tumours from patients with differing levels of pre-determined risk for lung cancer. Tumours with high or low epidemiological risk (LLP risk score) are being compared by Whole Genome Sequencing, microRNA profiling and DNA methylation analysis in order to define risk-associated (epi)genetic differences. This will provide a further parameter with which to test tumours with associated breath analysis and provide an insight into the molecular basis of VOC patterns associated with lung cancer risk.

In addition the in-vitro studies, the Liverpool University Partner they have reported on their continuation to collect breath samples from healthy volunteers who are part of one of the world’s largest population cohorts for the study of lung cancer risk. This population was used to generate the Liverpool Lung Project (LLP) risk model. LLP risk scores have been validated in independent datasets and are now being used to select subjects for the UK CT screening trial (UKLS). Within LCAOS, LLP risk score together with other epidemiological data will be analysed against breath VOC signatures in order to integrate breath analysis in the early detection setting.

Tel Aviv University has received the PTR-MS on August 2012. The PTR-MS was installed by Ionimed representatives and the Israeli team received an instruction and lecture regarding using the PTR-MS. They started to perform in-vitro assays in order to distinguish between the VOC of different kinds of lung cancer cells and also to find changes in VOC's profile after metabolic drug modification. They try to standardize the experiments and to reduce the background to minimum. They also collected breath samples from lung cancer patients at different stages of the diseases. They collect three bags at each time, two of them are absorbed on Tenax reusable tubes and sent to analysis at the Technion (artificial nose and GC-MS). The third bag is sampled on the PTR-MS. In the future they intend to compare the results from the three different devices.

                  Sampling with PTR-MS at our clinic                  TAU Team's trip to "Ayalon Institute Museum" in Rehovot

The University Complutense of Madrid has designed, optimized and tested a competitive unsupervised artificial neural network for two types of sensors as well as a new algorithm based on self-organizing maps/chaotic parameters to extract hidden information in huge databases. These chaotic parameters can be calculated following a really simple equation, and can even be done using a basic calculator. Part of their work was to classify the volatile compounds and to estimate their concentrations by Si NW FET and Neural networks. In order to classify volatile compounds and determine their concentrations, combinations of different types of silicon nanowire FET (Si NW FET) sensors and nonlinear algorithms have been tested. Methods based on Si NW FET sensors and supervised artificial neural networks (NNs) have been used to classify polar and non-polar volatile compounds. While validating this tool, no misclassifications were found. Similar NN algorithms and several types of Si NW FET sensors have been used to determine the concentration of the aforementioned compounds. Although in every case the mean prediction error values were less than 3%, when the most suitable Si NW FET sensor was used, the mean prediction error decreased to less than 1.50 %. In the light of these results, the combination of Si NW FETs and supervised artificial neural networks is a suitable tool to classify compounds as polar and non-polar, as well as to estimate their concentrations.



The Micronit Partner has fabricated microfluidic exposure cells made from glass and mounted functionalized silicon nanowire FETs which were produced at the Technion. This is the first time that the nanowire FETs are integrated with a microfluidic system and tests are currently underway to assess the performance.


Partner JLM Innovation presented the progress on the SiNW measurement platform. The system has been considereable improved from the previous version and software integration is ongoing. Two different analog frontends provide means to measure either 20 SiNW FET sensors or 20 resistive NP sensors.


The project partner Ionimed developed an instrument to produce artificial breath for sensor training and sensor calibration. A first prototype of such a Liquid Calibration Unit was further improved into a “ready-to-market” product, which is capable to efficiently evaporize mixtures of breath relevant chemicals to produce a gas of a stable and well defined concentrations representative for human breath. This LCU system was successfully coupled to sensor arrays. First tests clearly showed sensor responses to different concentrations produced by the LCU. The results of these initial experiments will trigger further improvements, such as a wider range of concentrations. A Proton-Transfer-Reaction Mass-Spectrometer, capable of quantitatively analyzing a large variety of volatile organic compounds (VOC) at trace concentrations, was implemented into the breath analysis lab of the Tel Aviv University. With the support of Ionimed, the researchers use this instrument for the validation and improvement of their sampling procedures, for VOC analysis of the head space of cancer cell lines and for breath gas analysis in real time, which is performed in parallel to the breath analysis by GC-MS and NA-NOSE at Technion.

LCaos Events, Publications and Awards

Here is a selection of some relevant workshops and conferences attended by various LCaos teams during the last period:

Prof. Hossam Haick made a presentation to The Lung Cancer Center, University of Colorado Cancer Center, Aurora, Colorado, USA, 19 January 2012.
Prof. Hossam Haick made a presentation to Fresenius Medical Care, Fresenius Headquarters, Bad Homburg v.d.H. Germany, 29 February 2012.
Prof. Hossam Haick made a presentation to The 46th Annual Conference of the Israel Society for Clinical Laboratory Sciences (ISCLS), Maccabiah Hotel, Kfar Maccabiah, Israel, 20 March 2012.
Prof. Hossam Haick made a presentation to The Partnership and Growth 2012 Prime Minister's Conference, Dan Carmel Hotel, Haifa, Israel, 20 March 2012.
Prof. Hossam Haick made a presentation to The Ministry of Security Annual Conference on Sensors for Dangerous Material, Tel-Aviv University, Tel-Aviv, Israel, 22 March 2012.
Prof. Hossam Haick made a presentation to The Israel-China Bilateral Conference on Nanotechnology, Dan Panorama Hotel, Tel-Aviv, Israel, 28-29 March 2012.
Dr. Jan Mitrovics, Mr. Sergi Udina, Prof. Hossam Haick and Prof. Jose Torrecilla attended and made presentations to IMCS 2012 - The 14th International Meeting on Chemical Sensors, Nuremberg, Germany, 20-23. May 2012.
Dr. Jan Mitrovics and Mr. Sergi Udina made presentations to SENSOR+TEST - The Measurement Fair - Presentation of the LCaos project at the booth of JLM Innovation GmbH on the trade show Sensor+Test 2012, Nuremberg, Germany, 22-24 May 2012.
Prof. Hossam Haick made a presentation to Center for Nanoscience and Nanotechnology, Hebrew University of Jerusalem, Jerusalem, Israel, 3 June 2012.
Prof. Hossam Haick made a presentation to The Annual Conference of Ministry of Health, ISROTEL-Princess Hotel, Eilat, Israel, 04 June 2012.
Prof. Hossam Haick made a presentation to The Annual Conference of the Israeli Occupational Medicine Association, Soker Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, 11 June 2012.
Prof. Jose Torrecilla made a presentation to 6th Annual International Conference on Mathematics & Statistics, Athens, Greece, 11-14 June 2012.
Prof. Hossam Haick made a presentation to The 9th National MUTAV Conference, The department for Science Education, Technion – Israel Institute of Technology, Haifa, Israel, 27 June 2012.
Prof. Jose Torrecilla made a presentation to the 20^th International Congress of Chemical and Process Engineering, Prague, Czech Republic, 25-29 August 2012.
Prof. Hossam Haick made a presentation to 1st Polish – Israeli Seminar on “Biomedical Engineering Approaches in Chronic Diseases, The International Center of Biocybernetics, Warsaw, Poland, 3-4 September 2012

Presentations given by different LCAOS members:

Prof. Hossam Haick made a presentation to Hôspital Marie Lannelongue, Le Plessis-Robinson, France, 6 May 2011
Prof. Hossam Haick made a presentation to The Schulich Faculty of Chemistry, Technion – IIT, Haifa, Israel, 10 May 2011
Prof. Hossam Haick made a presentation to The Faculty of Natural Science, Bethlehem University, West Bank, 11 May 2011
Prof. Hossam Haick made a presentation to The Biology Department of Technion, Technion – IIT, Haifa, Israel, 7 November 2011
Prof. Hossam Haick made a presentation to The Engineers Association, Pais Auditorium, Ramat-Gan, Israel, 16 November 2011
Prof. Hossam Haick made a presentation to BEZEQ EXPO, Exhibition Halls, Tel-Aviv, Israel, 20 December 2011
Prof. Hossam Haick made a presentation to The Department of Biochemistry and Molecular Biology, the Hebrew University Medical School, Ein-Karem, Jerusalem, Israel, 22 March 2012
Prof. Hossam Haick made a presentation to The ORT Biotech Workshop, Netanya Harmelin ORT College, Netanya, Israel, 27 March 2012
Prof. Hossam Haick made a presentation to The Schulich Faculty of Chemistry, Technion, IIT, Haifa, Israel, 10 May 2012
Prof. Hossam Haick made a presentation to The Faculty of Natural Science, Bethlehem University, West Bank, 11 May 2012
Prof. Jose Torrecilla made a presentation to Combination of self-organizing map and chaotic parameters for classifying anomalous digital signals Athens, Greece, 13 June 2012

Workshops attended by LCAOS team members:

Prof. Hossam Haick made a presentation to The Bnai-Zion Center Workshop, Bnai-Zion Medical Center, Haifa, Israel, 31 May 2011
Prof. Hossam Haick made a presentation to IASLC EDPC - Lung Cancer Biomarkers Workshop WCLC 2011, RAI Convention Centre, Amsterdam, the Netherlands, 1-2 July 2011
Prof. Hossam Haick made a presentation to Mérieux Research Workshop, Centre de Conférences Les Pensières, VEYRIER DU LAC, France, 24-25 October 2011
Prof. Hossam Haick made a presentation to PhD Student training on PTRMS at IONIMED June 2012, Austria, Innsbruck, Austria, 17-23 June 2012
Prof. Hossam Haick made a presentation to Technion-Cornell Healthier Life Workshop, Weill Cornell Medical College, New York City, New York, US, 26-27 July 2012

Relevant publications issued by LCaos teams:

Peled, N., Ionescu, R., Nol P., Barash, O., McCollum, M., VerCauteren, K., Koslow, M., Stahl, R., Rhyan, J., Haick, H., Detection of Volatile Organic Compounds in Cattle Naturally Infected with Mycobacterium bovis, Sensors & Actuators: B. Chemical, 171-172:588-594, 2012
Peled, N., Barash, O., Tisch, U., Bunn, P. A. Jr. R., Hirsch, F. R., Haick, H., Classification of the Lung Cancer Histology by Gold Nanoparticle Sensors, NanoMedicine, 8(5): 580-589, 2012
Peled, N., Hakim, M., Bunn, P. A. Jr. R., Miller, Y. E., Kennedy, T. C, Mattei, J., Mitchell, J. D, Weyant, M. J., Hirsch, F. R., Haick, H., Non-Invasive Breath Analysis for Solitary Pulmonary Nodules, J. Thoracic Oncology, 7:1528-1533, 2012
Hakim, M., Broza, Y. Y., Barash, O., Peled, N., Phillips, M., Amann, A., Haick, H., Formation of volatile organic compounds associated with lung cancer and possible biochemical pathways, Chemical Reviews, September 2012 (Peer Review)
Tisch, U., Peled, N., Billan, S., Phillip, M., Ilouze, M., Haick, H., Volatile Biomarkers in the Exhaled Breath for the Early Detection and Screening of Lung Cancer, Current Medical Literature – Lung Cancer 5(4):107-17, 2012
Wang, B., Stelzner, T., Dirawi, R.; Assad, O., Christiansen, S., Haick, H., Scaling Properties of Transistor Channels That Use Aligned Arrays of Si Nanowires, SMALL, 2012
Paska, Y., Haick, H., Interactive Effect of Hysteresis and Surface Chemistry on Gated Silicon Nanowire Gas Sensors, ACS Appl. Mater. Interf., 04.05.2012
Field, J. K., Smith, R. A., Aberle, D. R., Oudkerk, M., Baldwin, D. R., Yankelevitz, D., Pedersen, J. H., Swanson, S. J., Travis, W. D., Wisbuba, I. I., Noguchi, M., Mulshine, J. L., Haick, H., IASLC CT Screening Workshop 2011 Participants. International Association for the Study of Lung Cancer Computed Tomography, Screening Workshop 2011 Report, J. Thoracic Oncol. 7(1): 10-19, 2012
Bashouti, M. Y., Sardashti, K., Ristein, J., Christiansen, S. H., Early stages of oxide growth in H-terminated silicon nanowires: determination of kinetic behavior and activation energy, Physical Chemistry Chemical Physics,14(34):11877-81, 2012
Tisch, U., Haick, H., Arrays of Nanomaterial-based Sensors for Breath Testing, Volatile Biomarkers, 115-127, Anton Amann and David Smith (Eds.), 2012
Miekisch, W., Herbig, J., Schubert, J. K., Data interpretation in breath biomarker research: pitfalls and directions, J. Breath Research, IOP Publishing, J. Breath Res. 6, 036007, 10pp, 2012
Paska, Y., Stelzner, T., Christiansen, S., Haick, H., Enhanced Sensing of Nonpolar Volatile Organic Compounds by Silicon Nanowire Field Effect Transistors, ACS NANO, 5(7) 5620-5626, 2011
Haick, H., A Nanosensor Array for Detecting Volatile Biomarkers of Cancer, AIP Conf. Proc., 1362:15-16, 2011
Haick, H., Early Detection and Screening of Lung Cancer via Volatile Biomarkers. Proc. WCLC14, J. Thorac. Oncol., 6(6):20-25, 2011
Torrecilla, J. S., García, J., García, S., Matute, G., Rodríguez, F., Modelling of hydrocarbon solubility in isomeric ionic liquids using mathematical regressions, Separation Science & Technology, 47 (2012), 392-398, 2011

List of Exploitable Foregrounds developed via LCAOS project collaboration:

No.	Date	Title	Exploitable Foreground (description)	Exploitable product(s) or measure(s)	Sector(s) of application	Timetable for commercial use	Patents or other IPR exploitations (licenses)	Owner(s)
1	2012-09-29	Microfluidic exposure cell with sensor chips	A microfluidic exposure cell has been developed onto which a number of sensor chips are assembled using a flup-chip bonding approach. The exposure cell directs fluid from the inlet to the multitude of sensors. Electrical traces on the exposure cell provide a convenient means for making electrical contact between a readout instrument and the sensor chips.	Microfluidic exposure cell with sensor chips	Microtechnology, chemical sensing	Functional characterization needs to be completed first	The exposure cell concept can be exploited also for other sensing applications	MMBV
2	2012-06-27	FET characterization platform	A prototype measurement platform has been developed that can measure arrays of FET based sensors using a large range of gate voltage from -60 to +60V. Theese high voltages are typical requirements for nanowire based sensors.		Measurement instrumentation for nanotechnology	Redesign and certifications are required	The measurement platform can be adopted to a range of application by exchanging the analog frontend, firmware and software	JLM
3	2012-08-01	Liquid Calibration Unit	A Liquid Calibration Unit (LCU) has been developed, which can be used to produce precise trace gas concentrations of organic and inorganic compounds in gas. The gas matrix is humid and the admixing of CO2 allows simulating conditions found in breath gas. This device has been developed for calibration and training of sensors within LCAOS.	LCU - Liquid Calibration Unit	Analytics, Trace gas calibration	Product launch end 2012	The LCU will be marketed for versatile calibration of any kind of trace gas analyzers.	ION
4	2012-08-01	Active Liquid Flow Controller	In the frame of the development of the Liquid Calibration Unit, the need for a precise flow controller for liquids with low internal dead space volume arose. This lead to the development of the Ionimed active Liqud Flow controller, which has a dead-space volume of < 100 µl can control flows in the range of 0, 1, … 50 µl, with an active, i.e. self-priming, inlet.	aLFC - active Liquid Flow Controller	Microfluidics	Product launch 2013	The aLFC is a component of the LCU but will be marketet as a seperate OEM product.	ION

LCaos Exchanges and Position Openings

LCaos Newsletter - Issue no.1

Silvia Birsan — Mon, 12 Dec 2011 12:03:38 +0000

LCAOS newsletter

Welcome!

Dear Readers,

Welcome to the first issue of the LCaos Newsletter.

This newsletter is intended to bring to you the latest news coming from our FP7 LCaos consortium activities and achievements.

The opening section, LCaos Activities & Achievements describes the General Assembly Meetings which took place on April 4-5, 2011 in Haifa, Israel, and on November 23, 2011 in Erlangen, Germany. The LCaos Technical Developments section consists of information about the technical developments and current work status, as well as some major outcomes and plans for the future. The next section, LCaos Events, Publications and Awards advertises relevant workshops and conferences, and a list of publications and awards resulting from the project’s activities. Finally, the LCaos Exchanges and Position Openings section is dedicated to exchange opportunities and position openings. This is the place for each partner to advertise any MSc, PhD or post-doctoral positions, or any opportunities and exchanges for visiting researchers.

We really hope you will enjoy reading the newsletter! At the same time, we highly encourage all our readers to send us feedback and comments. We would also be pleased to receive photos and contributions from all our project partners!

Wishing you success in your research and lectures!

Prof. Hossam Haick and Dr. Silvia Birsan
LCaos Newsletter

LCaos Activities and Achievements

The two meetings of LCaos project have promised a good start to a successful project!

The kick off meeting of the LCaos project took place on the 4th and 5th of April 2011 at the Technion-IIT in Haifa, Israel. A concise overview of the project's objectives provided a general picture of the actions to be undertaken for an efficient, effective use of resources. This meeting was a good opportunity for the project partners to meet together and get to know people who are associated indirectly with the project such as Prof. Yachin Cohen, Dean of the Chemical Engineering Department; Mrs. Rita Bruckstein, Head of the Technion Research Development Foundation; Mr. Ofer Tsur from the Technion Research Authority; Mr. Alex Gordon, Head of the Technion Liaison Office; Mr. Jacky Lavan from the Technion Liaison Office; Dr. Zeev Gilkis, Head of Alfred Mann Institute for Biomedical Engineering at the Technion; and Mr. Amos Levav, the Technion's spokesman.

The meeting featured an Open Session, which included presentations by each project partner about their own organization and their ongoing research, as well as an overview of the overall LCaos project concepts and objectives. Brief presentations of the work packages, project deliverables, work strategies and approaches were presented by each WP leader during the Closed Session. The session also included planning and discussions led by Prof. Hossam Haick. In addition, the closed session hosted the 1st General Assembly Meeting, when Prof. Haick presented the general principles governing the LCaos Consortium and responsibilities of the parties, and during which Executive Board and Management Support Team members were elected. Dr. Silvia Birsan pointed out some issues related to information dissemination and external communication as well as administrative and financial aspects related to good, successful project management and monitoring. At the end, a tour of the LNBD (Laboratory for Nanomaterial-Based Devices) was organized. The laboratories house the most updated equipment used by the Technion team for their research.

LCaos participants in Akko, Israel, April 2011

On November 23, 2011, the 2nd General Assembly Meeting of the LCaos project took place at the Max-Planck Institute in Relangen, Germany.

The Open Session welcomed the participation of Siemens AG - Healthcare Sector and its representative, Dr. Thilo Elsaesser. The WP leaders presented the evolution of their project areas from the technical and scientific points of view – their progress and results from the beginning of the project until November 2011. During the Closed Session, there were discussions about future project strategies, some dissemination issues, and some administrative issues regarding the reporting and auditing processes. The meeting also included a tour of the laboratories directed by the Max-Planck Institute's LCaos project team leader, Dr. Silke Christiansen.

The participants very much appreciated all aspects of the meeting, since it provided the opportunity for a global view of the current progress and of the future plans.

LCaos Technical Developments

The Max-Planck Institute partner has produced, by bottom-up and top-down approaches, silicon nanowires (Si NWs) with an average diameter of 50 nm and different doping levels. All Si NWs were characterized by advanced imaging techniques, such as scanning electron microscopy (SEM) and transmission electron microscopy (TEM).

The Technion partner developed a spray-coating approach to allow aligned deposition of the Si NWs on a wide variety of solid and flexible devices. Additionally, the Technion partner has integrated either individual or an array of Si NWs with platforms of field effect transistors (FETs) and investigated a way to use the resulting devices as sensors under real-world conditions. In this endeavor, the Technion team made a marked advance when they developed a Si NW FET-based approach to detect polar and nonpolar gas analytes that are found in highly humidified samples.

The Micronit partner has developed three concepts for the manufacture of an integrated exposure cell. One concept was chosen for further development during the next stages of the LCaos project. The selected exposure cell concept is based on a glass microfluidic chip with thin film electrodes on the surface contacting the sensor chip. The prototype exposure cells will be manufactured during the next stage.

The JLM Innovation partner has started planning and testing data an acquisition board that will easily integrate with the existing measurement platform available at the Technion. This will allow better testing for new electronics measurements, and faster integration of the system with the MultiSens data acquisition and with the measurement platform. Work on the board has already started, too. The first boards will already be available in 2012.

The University of Madrid has designed, optimized and tested a competitive unsupervised artificial neural network for two types of sensors as well as a new algorithm based on self-organizing maps/chaotic parameters to extract hidden information in huge databases. These chaotic parameters can be calculated following a really simple equation, and can even be done using a basic calculator.

The Tel Aviv University and Liverpool University partners have started recruitment of lung cancer patients (adaptation of "Patient information leaflets" to the local SOPs, collection equipment for breath samples, familiarization of research nurses with the breath collection system, and starting the collection and storage of patient material) at different stages of the diseases. Additionally, these partners have established in vitro setups to sample headspace of lung cancer cells. The efforts of these two partners have been supported by a new central database for storage of patient and measurement data, established by the JLM Innovation partner.

The IONIMED partner has made very good advances in the development of an artificial breath system that could simulate disease states and healthy breath states. A user-friendly prototype is expected to be ready by March 2012. The same partner has made very good progress in the adaptation of proton transfer reaction mass spectrometry (PTR-MS) for online measurement of breath samples in the course of the LCaos project. This instrument will be delivered to the Tel Aviv University partner in the second quarter of 2012.

LCaos Events, Publications and Awards

Here is a selection of some relevant workshops and conferences attended by various LCaos teams:

Prof. Hossam Haick and Dr. Jan Metrovitcs attended and delivered talks at the International Symposium on Olfaction and Electronic Nose (ISOEN) 2011, Rockefeller University, New York, NY, US, 4 May 2011.
Prof. Hossam Haick attended and delivered an invited talk in the IASLC EDPC workshop and an invited talk during the Lung Cancer Biomarkers session at the WCLC 2011, Amsterdam, the Netherlands, 1-6 July 2011.
Dr. Nir Peled chaired the panel "Breath Test Diagnostic Biomarkers" in the IASLC EDPC– Lung Cancer Biomarkers Workshop, WCLC 2011, 1-2 July 2011.
Prof. John Field chaired the panel "SWOT on proposed biomarkers for the incorporation into the work-up of the detection of intermediate nodules in CT screening" in the IASLC EDPC–Lung Cancer Biomarkers Workshop WCLC 2011, 1-2 July 2011.
Dr. Radu Ionescu attended the IEEE Conference and presented the poster entitled "Development of an Extremely Selective E-nose Employing a Single Polycyclic Aromatic Hydrocarbon-based chemFET", Limerick, Ireland, 28-31 October 2011.

Relevant publications issued by LCaos teams:

Paska, Y.; Stelzner, T.; Tisch, U.; Assad, O.; Christiansen, S.; Haick, H.* Molecular Gating of Silicon Nanowire Field Effect Transistors with Nonpolar Analytes. ACS NANO 6(1), 335-345 (2012).
Paska, Y.; Stelzner, T.; Christiansen, S.; Haick, H.* Enhanced Sensing of Nonpolar Volatile Organic Compounds by Silicon Nanowire Field Effect Transistors, ACS NANO 5(7), 5620-5626 (2011).
Assad, O.; Leshansky, A. M.; Stelzner, T.; Christiansen, S.; Haick, H.* A Spray-Coating Route for Highly Aligned and Large-Scale Arrays of Silicon Nanowires. ACS NANO (accepted for publication).
Wang, B.; Stelzner, T.; Dirawi, R.; Assad, O.; Christiansen, S.; Haick, H.* Scaling Properties of Transistor Channels That Use Aligned Arrays of Si Nanowires. SMALL (submitted).
Torrecilla, J. S.; Calvo, C.; Ceno, C.; Matute G.; Rodriguez, F. Detection of the nature of signals by the combination of self-organizing maps and chaotic parameters. (submitted for publication).
Torrecilla, J.S., García, J., García, S., Matute, G., Rodríguez, F. Modelling of hydrocarbon solubility in isomeric ionic liquids using mathematical regressions. Sep. Sci. Technol. 47, 392-398 (2012).

LCaos Exchanges and Position Openings

We are pleased to announce an open position on the team of Prof. Hossam Haick (Technion):
Position: Full-time Data Analysis Software R&D
Responsibilities: (i) research, develop and implement data analysis algorithms & systems; and (ii) participate in the development of data analysis products
Education: M.Sc. / Ph.D. in a related field – electrical engineering, computer science, mathematics or related fields
Requirements: Machine learning / Pattern recognition analysis; MATLAB or object oriented design; advanced writing skills; strong capability for self-learning and independent work; good team work; rapidly acquire new skills and technologies; experience in building products (an advantage); fluency in English, and advanced presentation skills

For more details, please contact Mrs. Liat Tsuri (liatzuri@tx.technion.ac.il) or Prof Hossam Haick (hhossam@technion.ac.il)

Public attachement:

open position.pdf